Rathke cleft cyst (RCC) is a benign epithelial cyst believed to originate from the remnants of the Rathke pouch.

Typical imaging findings include a nonenhancing, noncalcified, intrasellar/suprasellar cyst with an intracystic nodule.

Rathke cleft cysts are most commonly hypodense on CT imaging. the lack of calcification, which helps distinguish RCC from craniopharyngiomas, which are typically calcified (90%). RCC are Hypodense (75%), mixed iso-/hypodense (20%), Hyperdense (5-10%), curvilinear calcification in the wall (10-15%). Does not enhance.