Growth hormone cell adenomas cause gigantism in children and acromegaly in adults. The most common cause of acromegaly in adults is pituitary adenoma.

Skull in acromegaly demonstrates calvarial thickening, frontal bossing, enlarged paranasal sinuses and enlarged sella turcica. The mandible also enlarges resulting in prognathism and increased gaps between the teeth.

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(PMID: 9352815)